Reliable and sophisticated chemistry underlies successful radiotracer studies and is an essential part of discovery and translational imaging. Invicro’s chemistry team has expertise in radiolabeling a wide range of compounds to support nonclinical and translational research.

Experience includes: 

  • small molecules
  • peptides
  • oligonucleotides
  • proteins
  • antibodies and antibody derivatives
  • nanoparticles
  • cells


Invicro’s capabilities include: 

  • Strategy and method development for novel radiolabeling, including large array of labeling techniques, allowing rapid labeling validation for novel compounds
  • Synthesis of PET and SPECT radiopharmaceuticals
  • A dedicated state-of-the-art cyclotron facility for production of short-lived isotopes
  • Quality control and immunoreactivity assays for tracer validation
  • Cell and/or tissue binding and cell internalization assay method development


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  • Experienced in projects with the following isotopes:

    PET Isotope 11C 68Ga 18F 64Cu 89Zr 124I 52Mn
    Half-life 20.3 min 67.7 min 109.8 min 12.7 hours 78.4 hours 4.2 days 5.6 days

    SPECT Isotope 99mTc 123I 188Re 203Pb 67Cu 201Tl 111ln 67Ga 186Re 177Lu 131I 125I 75Se
    Half-life 6.0 hours 13.2 hours 17 hours 51.9 hours 61.8 hours 72.9 hours 2.8 days 3.3 days 3.7 days 6.7 days 8.0 days 59.4 days 119.8 days

    Other Isotopes 213Bi 90Y 225Ac 32P 3H 14C
    Half-life 45.6 min 64.1 hours 10.0 days 14.3 days 12.3 years 5730 years

    In addition to the above isotopes, we also support conjugation with fluorophores as well as ‘cold’ radiolabeling with non-radioactive elements.

  • Invicro’s experience and expertise has been applied to over 70 radiotracer INDs and covers a broad range of targets including:

    5HT2a 5HT2a Adenosine A2a CB1
    Cholinergic transporter D2/D3 market for intrasynaptic dopamine (SPECT) DAT & SERT  Dopamine D2/D3 (PET)
    GABA GlyT1 H3 M2 muscarinic receptor
    mGluR 5 antagonist NET Neuroinflammation PBR (TSPO) NK1
    PDE10 SERT -amyloid protein Tau
    VMAT2 4β2 nicotinic agonist


  • Radiotracers are produced internally at three US sites and one UK site. Local distribution is available (please inquire for information/availability).

    The Invicro chemistry team has extensive expertise in the production and distribution of radiopharmaceuticals in the US, following GMP, USP 823, and CFR part 212 regulations.  We can produce multiple PET and SPECT tracers per day on the scale needed to satisfy clinical and non-clinical studies.

  • In addition to internal production, Invicro has expertise in the set up and management of radiotracer production sites in the United States, Europe and Australia.  This includes:

    • Technical site set up
    • Production and quality control validations
    • Trouble shooting assistance
    • Batch record creation and review