Radiochemistry

Delivering precision and efficiency for all your 
radiochemistry needs.

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Radiochemistry Services

Our radiochemistry team has radiolabeled hundreds of biological agents and small molecules for preclinical and clinical trial imaging. From targeted small molecules to monoclonal antibodies, peptides, and live cell labeling, we provide expertise across a diverse range of chemical entities.

Additionally, we offer ligand discovery support, leveraging our in-house expertise to optimize candidate selection.

  • 900+ agents radiolabeled
  • Extensive experience with US and UK/EU GMP regulatory requirements
  • 80+ IND submissions supported for novel radiotracers
  • Significant supply chain capabilities, supporting 300 global production centers
  • External manufacturing offering covering US, EU, APAC, and Oceania, including site identification, qualification, set up, validation, and oversight
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Capabilities

Our radiochemistry services are designed to reliably deliver high-quality radiotracers tailored precisely to meet your project needs.

Radiotracer Support

  • Radiohalogenations and radiometal chelations according to GMP manufacturing in accordance with FDA, MHRA, and EMA requirements
  • Expertise in automated synthesis modules
  • Ligands: low molecular weight, proteins, biologics
  • Cu-64, In-111, Zr-89, Ga-68, in-house cyclotrons for C-11/F-18 production
  • Rapid site-to-site method transfer, tracer manufacturing and shipping, and outsourcing of carbon-14 and tritium labeling

Quality Control

  • HPLC/UPLC, UV-Vis spectrophotometry, GC for residual solvent analysis
  • Bioactivity, immunoreactivity, and metabolite analysis (blood, urine, brain)
  • Cell/tissue binding and internalization assay development
  • CMP/urine metabolic health analysis, SDS-PAGE
  • Gamma counters, dose calibrators, radio-TLC scanners, and autoradiography
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Isotopes/Modalities

Perceptive has extensive experience working with widely used SPECT/PET and therapeutic isotopes.

We also support conjugation with fluorophores as well as ‘cold’ radiolabeling with non-radioactive elements.

PET Isotopes

  • Commonly used:
    • ¹¹C, ¹³N, ¹⁵O, ¹⁸F, ⁶⁴Cu, ⁶⁸Ga, ⁸⁹Zr, ¹²⁴I
  • Emerging & specialized:
    • ⁸⁶Y, ⁵²Mn

SPECT Isotopes

  • Short-lived:
    • ⁹⁹ᵐTc, ¹²³I
  • Long-lived:
    • ¹¹¹In, ¹²⁵I, ²⁰³Pb, ²⁰¹Tl, ⁶⁷Ga, ⁷⁵Se

Therapeutic Isotopes

  • Beta emitters:
    • ¹³¹I, ¹⁷⁷Lu, ⁹⁰Y, ¹⁸⁶Re, ¹⁸⁸Re
  • Alpha emitters:
    ²²⁵Ac, ²²⁷Ac, ²¹²Pb, ²¹¹At (notably emerging in alpha therapy)

Others:
• ¹⁶¹Tb, ⁶⁷Cu

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Specialized Experience in Astatine-211 (²¹¹At)

Perceptive is one of the few imaging and radiochemistry providers with proven radiolabeling capabilities using ²¹¹At, a highly promising alpha emitter in next-generation radiopharmaceutical therapies. Our team brings deep knowledge of its chelation chemistry, stability challenges, and safety protocols—enabling accelerated early-phase research in this emerging class of therapeutics.

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Medicinal Chemistry

Perceptive provides extensive support for small molecule ligand development, offering guidance on candidate selection from sponsor compound libraries or the production of custom precursors and standards for preclinical studies to maximize your chances of success. We also facilitate custom GMP precursor manufacturing through our trusted partners.

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Your Work is Global and So Are We

Perceptive offers in-house radiochemistry and clinical services, oversees clinical manufacturing at external sites, and produces and supplies radiotracers to imaging sites across the US and UK. We also facilitate access to a global network of radiotracer manufacturers, enabling GMP manufacturing at one of our sites with subsequent technology transfer to one of many perceptive-qualified sites based on geographical needs.

Our team also has extensive experience collaborating with external manufacturers to optimize and advance new tracers for IND applications and support NDA submissions for commercial use.

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How Can We Help?

Reach out today and one of our solution experts 
will be in touch to learn about your specific needs.

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Discover Our Clinical Trial Imaging Solutions

In-House Clinical and Imaging Centers

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Highly established clinical and imaging centers supporting first-in-human and multicenter studies.

Imaging Core Lab

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Proven expertise in delivering high-quality clinical trial imaging data at a global scale.