Expertise from having supported 750+ CNS clinical trials, including 250+ Alzheimer’s disease and 140+ Parkinson’s disease studies.
Our imaging core lab supports sponsors and CROs by delivering high-quality clinical trial imaging data through scientific collaboration and our scalable, global imaging core lab infrastructure.
Whether you’re developing a disease-modifying therapy for Alzheimer’s, a novel tracer for Parkinson’s, or exploring novel endpoints in rare neuropsychiatric disorders, Perceptive’s medical imaging core lab is your partner for precision, speed, and regulatory-ready data.
Perceptive has played a pivotal role in the clinical development and validation of nearly every amyloid and tau imaging tracer on the market. Our teams supported these agents from first-in-human studies through regulatory approval, giving us unmatched insight into tracer performance, quantification, and interpretation.
We bring proprietary analysis pipelines from the Parkinson’s Progression Markers Initiative (PPMI), including both PET and MR imaging workflows. These tools are optimized for disease progression modeling and understanding therapeutic response and have been validated across multicenter studies.
We enable regional quantification of amyloid and tau pathology to help differentiate disease stages and provide more granular insights to support exploratory endpoints in early and late-phase Alzheimer’s disease clinical trials.
Perceptive has established visual read paradigms to support eligibility, safety, and efficacy in CNS clinical trials with PET and/or MR images. The independent reads are performed by experienced neuroradiologists who are trained on study specific requirements, utilizing state-of-the-art technology.
Our close collaboration with preclinical and translational imaging leaders keeps us at the forefront of neuroscience research innovation. This connection to early science informs our clinical imaging strategies and ensures alignment with emerging targets and modalities.
Perceptive is well-established across APAC, including China, where we support large-scale CNS trials with local infrastructure, regulatory expertise, and site management. We deliver consistent imaging quality and meet faster timelines where other imaging vendors for clinical trials struggle to scale.
The CNS imaging team includes over 20 dedicated scientists and medical directors with deep expertise in neuroimaging biomarkers, disease progression modeling, operationalizing clinical trial imaging needs, and regulatory strategy. Our CNS imaging experts serve as an extension of your team, working closely on optimizing imaging protocols, so your trial is done right – the first time.
An acknowledged expert in neuroimaging of Alzheimer’s Disease (AD) and other forms of dementia, Prof. Cash brings 20 years of experience to Perceptive. He actively participates on various national and international committees, including DIAN, ADNI, GENFI, and has led the ISTAART Neuroimaging PIA, an organization of over 1700 neuroimaging researchers working in dementia. His research focuses on identifying early signs and characterizing the preclinical stages of dementias and how these changes can better inform clinical trials. He has set up, managed, and analyzed numerous large-scale multi-center studies analyzing biomarkers and brain imaging data.
Dr. Rohit Sood has contributed as a scientific lead on over 160 imaging clinical trials spanning the entire spectrum, from early to late phase, across multiple therapeutic areas including more than 40 in neurological indications. He has contributed to the science on several Neuro-oncology, Neurodegenerative, Neuropsychiatry and Rare disease clinical trials and has collaborated with our study sponsors to develop criteria for evaluating the eligibility, efficacy, and safety aspects of their studies. As a senior member of several scientific organizations and societies, Dr. Sood is actively engaged in furthering the science in the clinical trial space.
Dr. Elif Sikoglu brings 20+ years of experience in imaging, specifically focusing on advanced MRI applications to understand disease mechanisms and treatment effects. She has been scientific lead for over 200 imaging clinical trials (early to late phase) across multiple neurological and psychiatric indications including Alzheimer’s and Parkinson’s disease, Multiple Sclerosis, Stroke, mood disorders and rare diseases. She has played critical role in development and implementation of acquisition guidelines, visual read review criteria and quantitative analysis approaches. Elif provides scientific leadership in adaptation and operationalization of imaging biomarkers in CNS clinical trials.
Dr. Samuel Lockhart is a Neuroscientist with 15+ years’ experience investigating late-life brain health using imaging, cognitive, and biomarker data, aiming to develop interventions for preventing disease and decline. Having worked with multiple NIH Alzheimer’s Disease Research Centers (ADRCs), Dr. Lockhart has over 90 publications on aging and neurodegenerative disease, was founding Co-Leader of the Wake Forest ADRC Imaging Biomarker Core, and led brain imaging ancillaries to clinical trials impacting brain health. Sam continues to provide industry scientific leadership in the design and implementation of imaging biomarker solutions in clinical trials.
As a neuroscience imaging CRO, Perceptive offers a comprehensive suite of clinical trial imaging services tailored to the unique demands of CNS studies:
Protocol and imaging charter development
Regulatory consultation and IND/CTA support
Site selection, qualification, and training
Centralized blinded independent reads (PET, DaT SPECT, MRI)
Image acquisition and data collection with fast turn-around-time image QC and data transfer
Quantitative analysis: SUVR, Centiloid, Extent, SBR, volumetrics, functional/structural connectivity, perfusion, brain metabolites
Imaging biomarker strategy for eligibility, efficacy, and safety endpoints
Continuous scientific support to drive your trial's success
Perceptive can work with any CNS indication and modality (including exploratory tracers) to support qualitative and quantitative endpoints, including but not limited to:
Learn how Perceptive enabled a top-5 pharmaceutical sponsor to meet aggressive timelines for a pivotal Alzheimer’s trial evaluating an amyloid-targeting therapy.
Perceptive Imaging supports a full spectrum of quantitative imaging methods tailored to the complexity of CNS clinical trials. Our analysis pipelines are validated, regulator-aligned, and optimized for multicenter studies—ensuring consistency, reproducibility, and statistical power across imaging modalities and endpoints.
All imaging data undergo rigorous quality control, including automated triage, manual review, and centralized adjudication by subspecialty-trained readers. Our pipelines are CFR Part 11–compliant and designed to support both primary and exploratory endpoints in regulatory submissions.
