Our analytics platform lies at the heart of Invicro’s unique capabilities. We employ a data-driven approach to study design and execution, which lends itself to meaningful data. Once the raw data are collected, Invicro can leverage our computer science, biomedical engineering, mathematics, optics and image processing background for sophisticated analytics.
We have developed and validated analysis protocols across multiple imaging modalities, including but not limited to PET, SPECT, CT, MR, fluorescence, autoradiography, histology, and microscopy. These protocols have spanned numerous disease areas such as oncology, neurology, cardiology, and pulmonary in both the clinical and preclinical space.
Analysis and modeling can be customized to lab-specific efforts. We have built a team of analysts and developers covering a wide breadth and expertise and who pride themselves on both novel analysis development and fast, accurate turnaround for routine protocols. We can accommodate many applications, and studies of nearly any size.
For sponsors interested in translating analysis methodology into their clinical trials, we can technically validate data processing workflows into our Clinical Core Lab. Data analysis routines can be deployed and GxP validated for incorporation into single-site and multi-center clinical trials.
The links below are a few highlighted examples of Invicro image analytics case studies. Our capabilities are extensive, so please contact us for how our work may apply to your research study
Tumor time-activity curves (TACs) were generated for the 89Zr-labeled antibody Trastuzumab for several levels of tumor antigen expression and vascularity.
An automated tool was developed to segment four teeth in focused head CT scans of rhesus monkeys using a dual-resolution multi-atlas segmentation method.
Endogenous porphyrin content is enhanced and imaged using cryofluorescence tomography.
The structural strength of posterior lumbar fusions (PLF) in rabbit vertebrae were estimated using an analysis based on electrical conductivity.
A software toolkit was developed in MATLAB (MathWorks, Inc., Natick, MA) and implemented as a plugin to VivoQuant™ to calculate the voxel-wise percentage of lipids and water using multi-echo MRI images.
Bony implants are segmented and analyzed in a longitudinal study after leveraging segmentation and inter-time registration of rigid vertebrae.
Cryofluorescence tomography is used to simultaneously recover a snapshot of the renal clearance of two distinct tracers, one injected intravenously and one injected intrathecally.
Custom mechanistic modeling and simulation tools are used to bring a rational design approach to the PET/CT protocol for a first-in-human diagnostic peptide.
Ten large hounds were imaged with a combination of in vivo 124I PET/CT, in vivo 125I Planar Scintigraphy, and ex vivo quantitative 3D autoradiography to evaluate the pharmacokinetics and biodistribution of a compound in a study of canine pancarpal arthrodesis.