Advanced Brain Analysis Module

Designed to provide a rigorous and repeatable means of analyzing pre-clinical brain images, inviCRO's brain analysis tools will improve the quality and efficiency of your site's neurological studies. The tools quantify single acquisition and/or dynamic response across brain regions in PET, SPECT and/or MRI brain scans. Automated fusion routines register an application-specific brain atlas to pre-clinical image data (or vice versa) and advanced statistical analysis methods are employed to provide rapid and thorough region-specific volume and uptake quantification.

Key Features

• Fully or semi-automated brain segmentation from pre-clinical image data eliminates the need to hand-draw ROIs.
• 2D and 3D analysis options available.
• A flexible atlas/key structure enables user-definable region groups.
• A convenient interface allows easy QC and intuitive reorientation tools enable follow-up analysis incorporating manual correction.
• Batch-process possible hundreds of data sets.
• Default mouse and rat atlases provided with user-provided extensions for other animals and/or site-specific rodent atlases supported.
• Optional resampling (i.e., produce results with subsampled voxels).
• Export results as spreadsheets, allowing for easy post-processing using your site's pre-existing tools.

Analysis of Nuclear Medicine Brain Images

The nuclear medicine brain-atlas processing module provides quantification and analysis for neurological pre-clinical images. Anatomical data (i.e., a CT of the head region) are used for registration of a customizable brain atlas to PET or SPECT data, providing region-based volume and quantification information. Choose between fitting the data to an atlas or vice versa depending on the importance of data sensitivity and region preservation to your application. When the analysis is complete, the tool provides comprehensive output that is designed to simplify any additional processing.

Analysis of MRI Brain Images

inviCRO’s MRI brain-atlas processing tools offer rapid analysis of structural and functional pre-clinical data. A wide range of analysis options are used to generate output images and spreadsheets, valuable in the assessment of volumetric and/or signal changes for structural or functional procedures.

The module first identifies matching 2D MR slices with their corresponding atlas slice. Then, a semi-automated 2D slice-by-slice segmentation routine finds the brain region and allows for customization of the ROI with just a few clicks. Following the registration of the matched atlas slices to their MR counterparts, ignore "bad" slices or time points with the tool's automated and/or user-provided “avoidance” feature if necessary. Region, slice, and voxel-based AFNI processing, including percent-change maps and optional hemisphere processing, is then performed, generating quantitative and qualitative output.