2011-07-01
A compartmental model of molecular transport in tumors has been integrated into VivoQuant to provide imaging scientists with a tool to simulate tumor accumulation over time for common tumor-targeting scaffolds (e.g., IgGs, minibodies, peptides). Scientists input the biological and image study parameters that affect tumor accumulation (affinity, antigen density, injected activity, dose, etc.) and the tool calculates specific activity, isotope-to-ligand ratio, and initial blood concentration from the input parameters and displays the model simulation results in various units (%ID, %ID/g, μCi, μCi/mm3, nM, SUV).
inviCRO has developed several compartmental and distributed PK models to predict the accumulation of radiolabeled biologics in tumors and to estimate tumor properties in vivo (i.e. antigen density and drug internalization) from molecular imaging data. Validated mathematical models allow for improved fundamental understanding of imaging data and how it relates to drug distribution and disease characterization.
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