New Developments
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inviCRO Announces the Release of VivoQuant 1.20 - The Preferred Solution for Multi-modal Image Viewing and Analysis
2011-11-10
| inviCRO is excited to announce the release of VivoQuant 1.20. With new and expanded functionality, the VivoQuant image viewing and analysis platform offers more power, flexibility, and efficiency than every before. New capabilities and ease-of-use features make accomplishing research tasks faster and easier. VivoQuant now have access to an improved 3D ROI tool, Bruker and Aspect Imaging MR data loading support, PET/MR viewing support, scriptable workflows, expanded DICOM support, and much more! Furthermore, inviCRO has recently partnered with two leading manufacturers of pre-clinical MR systems to distribute VivoQuant as their multi-modal solution for viewing and analyzing image data. |
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2011-07-01
A compartmental model of molecular transport in tumors has been integrated into VivoQuant to provide imaging scientists with a tool to simulate tumor accumulation over time for common tumor-targeting scaffolds (e.g., IgGs, minibodies, peptides). Scientists input the biological and image study parameters that affect tumor accumulation (affinity, antigen density, injected activity, dose, etc.) and the tool calculates specific activity, isotope-to-ligand ratio, and initial blood concentration from the input parameters and displays the model simulation results in various units (%ID, %ID/g, μCi, μCi/mm3, nM, SUV).
inviCRO has developed several compartmental and distributed PK models to predict the accumulation of radiolabeled biologics in tumors and to estimate tumor properties in vivo (i.e. antigen density and drug internalization) from molecular imaging data. Validated mathematical models allow for improved fundamental understanding of imaging data and how it relates to drug distribution and disease characterization.
Click here to read more.
Email
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for a trial VivoQuant license or to inquire further. |
Recent Publications: Assessing Antibody Pharmacokinetics in Mice with In Vivo Imaging
2011-05-31
 inviCRO announces the publication of a recent article in the Journal of Pharmacology and Experimental Therapeutics authored by Dr. Hoppin, Dr. Orcutt, Dr. Hesterman, and Dr. Lackas at inviCRO along with collaborators at the University of Massachusetts Medical School and Millennium Pharmaceuticals. The article, Assessing Antibody Pharmacokinetics in Mice with In Vivo Imaging, was selected for the cover story in the May 2011 edition of JPET. The article reviews basic principles of radiolabeling and imaging methods relevant to antibodies with a focus on practical considerations of study design and execution. The article includes detailed tables with information on imaging sensitivity, resolution, radiochemical properties, and cost of common SPECT and PET isotopes. Images and analysis from a case study are presented. Image data were processed to assess the biodistribution of 111In-labeled specific and non-specific antibodies in xenograft tumors and other regions of interest at select times out to 96 hours post-injection. The figure displayed on the left illustrates the powerful qualitative and quantitative advancements that have been made in the field of small-animal molecular imaging. A, maximum intensity projections of SPECT (color) and CT (gray-scale) of two xenograft mice injected with a 111In-labeled specific antibody (top) or 111In-labeled nonspecific antibody (bottom). B, surface plots displaying radial tumor profiles of activity distribution as a function of time for the specific antibody (left), nonspecific antibody (middle), and merge (right). To view this article online, please click here. To request more information about inviCRO’s imaging services, please email
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Figure 1 from Jack Hoppin, Kelly Davis Orcutt, Jacob Y. Hesterman, Matthew D. Silva, Dengfeng Cheng, Christian Lackas, and Mary Rusckowski Assessing Antibody Pharmacokinetics in Mice with In Vivo Imaging J Pharmacol Exp Ther May 2011 337:350-358
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VivoQuant's Latest Tool - 3D ROI Segmentation
2011-04-25
 inviCRO's VivoQuant software now features a powerful 3D ROI segmentation tool. This easy-to-use function allows users to classify for the first time each individual voxel of a three dimensional volume dataset. The 3D ROI tool can be utilized for manual analysis of individual images, or in conjunction with inviCRO’s automatic segmentation tools for processing data in batch. VQ’s tools, including 3D ROI, supports multi-modal and dynamic data. The 3D ROI tool is supported by VivoQuant’s standard toolboxes and viewing displays, and also provides time-saving functionality For example, segment a fixed ROI only once and use it to evaluate other datasets of choice. For iPACS users,ROIs and quantification results can be stored to and later retrieved from iPACS with one click. Test versions of the new 3D ROI tool are available as part of our beta testing program (Click for download link)
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FLARE™ Data Management
2010-06-08
inviCRO and Beth Israel Deaconess Medical Center (BIDMC), a teaching hospital of Harvard Medical School, are collaborating on a special project to develop a data management system for the FLARE™ (FLuorescence-Aided Resection and Exploration) imaging system. The FLARE instrument, developed by Dr. John Frangioni of BIDMC, is an image-guided surgery tool that uses near-infrared light to visualize cancerous tissue in real-time. The collaboration addresses the need for a streamlined data storage, retrieval, viewing and analysis for large-scale image data generated by FLARE systems undergoing testing at multiple clinical sites worldwide.
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